Ethyl N-[(4-methylphenyl)sulfonyl]glycinate
Ethyl N-[(4-methylphenyl)sulfonyl]glycinate
CAS: 5465-67-8
Molecular Formula: C11H15NO4S
Ethyl N-[(4-methylphenyl)sulfonyl]glycinate - Names and Identifiers
Ethyl N-[(4-methylphenyl)sulfonyl]glycinate - Physico-chemical Properties
| Molecular Formula | C11H15NO4S |
| Molar Mass | 257.31 |
| Density | 1.229±0.06 g/cm3(Predicted) |
| Melting Point | 64-66 °C |
| Boling Point | 384.7±52.0 °C(Predicted) |
| Flash Point | 186.5°C |
| Vapor Presure | 4.02E-06mmHg at 25°C |
| pKa | 9.25±0.50(Predicted) |
| Refractive Index | 1.525 |
Ethyl N-[(4-methylphenyl)sulfonyl]glycinate - Introduction
Ethyl N-[(4-methylphenyl)sulfonyl]glycinate is also known as ethyl ester of tosylglycine (Ethyl N-[(4-methylphenyl)sulfonyl]glycinate). Its properties, uses, preparation methods and safety information are as follows:
Nature:
Ethyl N-[(4-methylphenyl)sulfonyl]glycinate is a white or off-white crystalline solid with chemical stability. It is soluble in organic solvents such as alcohols and ketones at normal temperature, and hardly soluble in water. The chemical formula of this compound is C12H15NO4S and the molecular weight is 269.32.
Use:
Ethyl N-[(4-methylphenyl)sulfonyl]glycinate is a commonly used organic synthesis intermediate. It can be used in the synthesis of other compounds, such as the construction of pharmaceutical and pesticide active molecules. In addition, it can be used in the synthesis of biologically active molecules and as a bactericide and preservative.
Preparation Method:
Ethyl N-[(4-methylphenyl)sulfonyl]glycinate are generally prepared by reacting benzenesulfonyl chloride with glycine ethyl ester. First, benzenesulfonyl chloride and sodium carbonate solution are reacted under alkaline conditions to form sodium methylbenzenesulfonate. Then, sodium methylbenzenesulfonate was reacted with glycine ethyl ester under alkaline conditions to give Ethyl N-[(4-methylphenyl)sulfonyl]glycinate.
Safety Information:
Ethyl N-[(4-methylphenyl)sulfonyl]glycinate does not cause obvious danger under normal conditions. However, as any chemical, it still needs to be properly disposed. It is recommended to wear suitable personal protective equipment such as gloves, goggles and protective clothing during use or operation. Also, avoid ingestion, inhalation or contact with skin and eyes. Please read and follow the safety instructions carefully before use. In the event of an accident, the doctor should be called immediately and the relevant information should be provided to the doctor.
Nature:
Ethyl N-[(4-methylphenyl)sulfonyl]glycinate is a white or off-white crystalline solid with chemical stability. It is soluble in organic solvents such as alcohols and ketones at normal temperature, and hardly soluble in water. The chemical formula of this compound is C12H15NO4S and the molecular weight is 269.32.
Use:
Ethyl N-[(4-methylphenyl)sulfonyl]glycinate is a commonly used organic synthesis intermediate. It can be used in the synthesis of other compounds, such as the construction of pharmaceutical and pesticide active molecules. In addition, it can be used in the synthesis of biologically active molecules and as a bactericide and preservative.
Preparation Method:
Ethyl N-[(4-methylphenyl)sulfonyl]glycinate are generally prepared by reacting benzenesulfonyl chloride with glycine ethyl ester. First, benzenesulfonyl chloride and sodium carbonate solution are reacted under alkaline conditions to form sodium methylbenzenesulfonate. Then, sodium methylbenzenesulfonate was reacted with glycine ethyl ester under alkaline conditions to give Ethyl N-[(4-methylphenyl)sulfonyl]glycinate.
Safety Information:
Ethyl N-[(4-methylphenyl)sulfonyl]glycinate does not cause obvious danger under normal conditions. However, as any chemical, it still needs to be properly disposed. It is recommended to wear suitable personal protective equipment such as gloves, goggles and protective clothing during use or operation. Also, avoid ingestion, inhalation or contact with skin and eyes. Please read and follow the safety instructions carefully before use. In the event of an accident, the doctor should be called immediately and the relevant information should be provided to the doctor.
Last Update：2024-04-09 21:11:58
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CAS: 5465-67-8
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CAS: 5465-67-8
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